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Research Focus


Bioorganic Chemistry, Medicinal Chemistry, Biophysics


The research in our laboratory is focused on the expansion of interdisciplinary research at the interface of chemistry and biology to discover novel peptidomimetics and other small molecules that modulate protein-protein interactions involved in critical cellular processes. Understanding how these compounds interact with proteins will help to reveal mechanisms governing cell activities. We are particularly interested in developing compounds that lead to the design of novel therapeutics potentially targeting cancer, HIV, and Alzheimer’s disease, etc.

1. Design of novel non-natural peptidomimetics mimicking bioactive peptides

The principal goal of this project is to design novel peptidomimetics termed "AApeptides" that mimic the distance relationships and relative positions of amino acid side chains along natural peptides. These AApeptides are designed based on chiral PNA backbones. Such peptide mimics may be used as a valuable tool to probe or modulate cellular processes such as protein-protein interactions and cell signaling. They also have great potential to identify novel drug candidates or lead compounds. The primary aim in this project is to expand upon this growing research area in chemical biology.

 

We greatly appreciate the generous support of

Division of Chemistry

Chemistry of Life Processes (CLP)

 

Division of Materials Research

Biomaterials

 

 

 

 

 

 

 
 

 

Previous support

KC
 

Kimberly-Clark, PI

FOH
 

Bankhead-Coley Cancer Program, PI

 

Elsa U. Pardee Foundation

 

 

Elsa U. Pardee Foundation, PI

 

 

 

NIH-NIAID, PI