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PUBLICATIONS (*Corresponding author)


From Independent Career:

 

2017

90. Yan Shi, Sridevi Challa, Peng Sang, Fengyu She, Chunpu Li, Geoffrey M. Gray, Alekhya Nimmagadda, Peng Teng, Timothy Odom, Yan Wang, Arjan van der Vaart, Qi Li,* and Jianfeng Cai.* One-Bead-Two-Compound Thioether Bridged Macrocyclic γ-AApeptide Screening Library against EphA2, J. Med. Chem., 2017, Accepted. Link

89. Peng Teng, Alekhya Nimmagadda, Ma Su, Yuzhu Hong, Ning Shen, Chunpu Li, Ling-Yu Tsai, Jessica Cao, Qi Li,* and Jianfeng Cai.* Novel Bis-Cyclic Guanidines as Potent Membrane-Active Antibacterial Agents with Therapeutic Potential, Chem. Commun., 2017, 53, 11948-11951. Link

88. Chao Zhang, Xiao cheng, Mengkun Chen, Jie Sheng, Jing Ren, Zhongying Jiang,* Jianfeng Cai,* and Yong Hu.* Fluorescence guided photothermal/photodynamic ablation of tumours using pH-responsive chlorin e6-conjugated gold nanorods, Colloids Surfaces B: Biointerfaces, 2017, Accepted. Link

87. Ma Su, Donglin Xia, Peng Teng, Alekhya Nimmagadda, Chao Zhang, Timothy Odom, Annie Cao, Yong Hu, and Jianfeng Cai.* Membrane-Active Hydantoin Derivatives as Antibiotic Agents, J. Med. Chem., 2017, 60, 8456-8465. Link

86. Hua Sui, Jihui Zhao, Lihong Zhou, Haotian Wen, Wanli Deng, Chunpu Li, Qing Ji, Xuan Liu, Yuanyuan Feng, Ni Chai, Qibo Zhang, Jianfeng Cai, Qi Li.* Tanshinone IIA inhibits β-catenin/VEGF-mediated angiogenesis by targeting TGF-β1 in normoxic and HIF-1αinhypoxicmicroenvironments in human colorectal cancer, Cancer Lett., 2017, 402, 86-97. Link

85. Zhe Zhang, Heng Wang, Xu Wang, Yiming Li, Bo Song, Olapeju Bolarinwa, R. Alexander Reese, Tong Zhang, Xu-Qing Wang, Jianfeng Cai, Bingqian Xu, Ming Wang,* Changlin Liu,* Hai-Bo Yang, and Xiaopeng Li.* Super Snowflakes: Step-Wise Self-Assembly and Dynamic Exchange of Rhombus Star-Shaped Supramolecules, J. Am. Chem. Soc., 2017, 139, 8174-8185. Link

84. Peng Teng, Ning Ma, Darrell Cole Cerrato, Fengyu She, Timothy Odom, Xiang Wang, Li-June Ming, Arjan van der Vaart, Lukasz Wojtas, Hai Xu,* and Jianfeng Cai.* Right-Handed Helical Foldamers Consisting of de novo D-AApeptides, J. Am. Chem. Soc., 2017, 139, 7363-7369. Link

83. Jianjun Pan,* Prasana K. Sahoo, Annalisa Dalzini, Zahra Hayati, Chinta M. Aryal, Peng Teng, Jianfeng Cai, Humberto Rodriguez Gutierrez, Likai Song.* Membrane Disruption Mechanism of a Prion Peptide (106-126) Investigated by Atomic Force Microscopy, Raman and Electron Paramagnetic Resonance Spectroscopy, J. Phys. Chem. B., 2017, Accepted. Link

82. Hai Xu,* Siqi Zhao, Xiang Xiong, Jinzhi Jiang, Wei Xu, Daoben Zhu, Yi Zhang, Wenjie Liang, Jianfeng Cai.* Atomic Force Microscope characterization of self-assembly behaviors of cyclo[8] pyrrole on solid substrates, Chem. Phys. Lett., 2017, 647, 151. Link

81. Nawal K Khadka; Peng Teng, Jianfeng Cai, and Jianjun Pan.* Modulation of Lipid Membrane Structural and Mechanical Properties by a Peptidomimetic Derived from Reduced Amide Scaffold. Biochim. Biophys. Acta., 2017, 1859, 734-744. Link

80. Alekhya Nimmagadda, Yan Shi and Jianfeng Cai.* γ-AApeptides as a new strategy for therapeutic development. Curr. Med. Chem., 2017, Accepted. Link

79. Olapeju Bolarinwa, Alekhya Nimmagadda, Ma Su, and Jianfeng Cai.* Structure and Function of AApeptides. Biochemistry, 2017, 56, 445-457. Link

78. Alekhya Nimmagadda, Xuan Liu, Peng Teng, Ma Su, Yaqiong Li, Qiao Qiao, Nawal K Khadka, Xiaoting Sun, Jianjun Pan, Hai Xu,* Qi Li,* and Jianfeng Cai.* Polycarbonates with Potent and Selective Antimicrobial Activity toward Gram-Positive Bacteria. Biomacromolecules, 2017, 18, 87-95. Link

77. Peng Sang, Yan Shi, Peng Teng, Annie Cao, Hai Xu, Qi Li, and Jianfeng Cai.* Antimicrobial AApeptides. Curr. Top. Med. Chem., 2017, 17, 1266-1279. Link

2016

76. Peng Teng, Da Huo, Alekhya Nimmagadda, Jianfeng Wu, Fengyu She, Ma Su, Xiaoyang Lin, Jiyu Yan, Annie Cao, Chuanwu Xi,* Yong Hu,* and Jianfeng Cai.* Small antimicrobial agents based on acylated reduced amide scaffold. J. Med. Chem., 2016, 59, 7877–7887. Link

75. Chian Sing Ho; Nawal Khadka, Fengyu She; Jianfeng Cai, and Jianjun Pan.* Influenza M2 Transmembrane Domain Senses Membrane Heterogeneity and Enhances Membrane Curvature. Langmuir, 2016, 32, 6730-6738. Link

74. Fengyu She, Olapeju Oyesiku, Peiguang Zhou, Shiming Zhuang, David W. Koenig, and Jianfeng Cai.* The development of Antimicrobial γ-AApeptides. Future Med. Chem., 2016, 8, 1101. Link

73. Fengyu She, Alekhya Nimmagadda, Peng Teng, Ma Su, Xiaobing Zuo, and Jianfeng Cai.* Helical 1:1 α/sulfono-γ-AA heterogeneous peptides with antibacterial activity. Biomacromolecules, 2016, 17, 1854–1859. Link

72. Pavanjeet Kaur, Yaqiong Li, Jianfeng Cai,* and Likai Song.* Selective Membrane Disruption Mechanism of an Antibacterial γ-AApeptide Defined by EPR Spectroscopy. Biophys. J., 2016, 110, 1789-1799. Link

71. Peng Teng, Yan Shi, Peng Sang, and Jianfeng Cai.* γ-AApeptides as a new class of peptidomimetics. Chem. Eur. J., 2016, 22,2-11. Link

70. Yan Shi, Peng Teng, Peng Sang, Fengyu She, Lulu Wei, and Jianfeng Cai.* γ-AApeptides: design, structure, and applications. Acc. Chem. Res., 2016, 49, 428–441. Link

69. Hai Xu,* Siqi Zhao, Yang Ren, Wei Xu, Daoben Zhu, Jinzhi Jiang and Jianfeng Cai.* Primary Investigation of optical limiting performance of Cyclo [8] pyrrole with wide optical limiting window. RSC Advances, 2016, accepted. Link

68. Chian Sing Ho, Nawal K Khakda, Fengyu She, Jianfeng Cai, Jianjun Pan.* Polyglutamine Aggregates Impair Lipid Membrane Integrity and Enhance Lipid Membrane Rigidity. Biochim. Biophys. Acta., 2016, 1858, 661-670. Link

67. Yan Wang, Frankie Costanza, Alekhya Nimmagadda, Daqian Song, Jianfeng Cai,* and Qi Li.* PEG-poly (amino acid)s/MicroRNA complex nanoparticles effectively arrest the growth and metastasis of colorectal cancer. J. Biomed. Nanotechnol., 2016, 12, 1510-1519. Link

66. Xiaoyang Lin, Ge Bai, Kyle Sutherland, Frankie Costanza, Kurt Breitenkamp, Kevin Sill, Jianfeng Cai,* and Chuanhai Cao.* Polymer-Encapsulated Aβ Peptide Fragments as an Oligomeric-Specific Vaccine for Alzheimer's disease. J. Biomed. Nanotechnol., 2016, 12, 1421-1430. Link

65. Haifan Wu, Jinzhi Jiang, Hai Xu, Qi Li, Jianfeng Cai.* RGD mimetic γ-AApeptides and methods of use us 20140004039 a1: a patent evaluation. Expert Opin. Ther. Pat., 2016, 26, 131-137, Link.

2015

64. Fan Chao, Lu Chen, Qingling Huang, Tao Shen, Eric A. Welsh, Jamie K. Teer, Jianfeng Cai, W. Douglas Cress, and Jie Wu.* Overexpression of major CDKN3 transcripts is associated with poor survival in lung adenocarcinoma. Br. J. Cancer, 2015, 113, 1735–1743. Link.

63. Hua Sui, Hanchen Xu, Qing Ji, Xuan Liu, Lihong Zhou, Haiyan Song, Xiqiu Zhou, Yangxian Xu, Zhesheng Chen, Jianfeng Cai, Guang Ji, Qi Li.* 5-hydroxytryptamine receptor (5-HT1DR) promotes colorectal cancermetastasis by regulating Axin1/β-catenin/MMP-7 signaling pathway. Oncotarget. 2015, 6, 25975-25987. Link

62. Haifan Wu, Qiao Qiao, Peng Teng, Yaogang Hu, Dimitrios Antoniadis, Xiaobing Zuo, Jianfeng Cai.* A new class of heterogeneous helical peptidomimetics. Org. Lett. 2015, 17, 3524-3527. Link

61. Yaqiong Li, Haifan Wu, Peng Teng, Ge Bai, Xiaoyang Lin, Xiaobing Zuo, Chuanhai Cao, Jianfeng Cai.* Helical antimicrobial sulfono-γ-AApeptides. J. Med. Chem, 2015, 58, 4802–4811, Link

60. Yuxia Hao, Ge Bai, Junping Wang, Longfeng Zhao, Kyle Sutherland, Jianfeng Cai and Chuanhai Cao.* Identifiable biomarker and treatment development using HIV-1 long term non-progressor sera. BMC Immunol, 2015, 16:25, Link.

59. Shruti Padhee, Yaqiong Li, Jianfeng Cai.* Activity of lipo-cyclic γ-AApeptides against biofilms of staphylococcus epidermidis and pseudomonas aeruginosa. Bioorg. Med. Chem. Lett., 2015, 25, 2565–2569. Link.

58. Xuan Liu, Qing, Ji, Naijing Ye, Hua Sui, Lihong Zhou, Huirong Zhu, Zhongze Fan, Jianfeng Cai, and Qi Li.* Berberine Inhibits Invasion and Metastasis of Colorectal Cancer Cells via COX-2/PGE2 Mediated JAK2/STAT3 Signaling Pathway. PLoS One, 10(5): e0123478. Link

57. Qing Ji, Xuan Liu, Zhifen Han, Lihong Zhou, Hua Sui, Linlin Yan, Haili Jiang, Jianlin Ren, Jianfeng Cai, and Qi Li.* Resveratrol suppresses epithelial-to-mesenchymal transition in colorectal cancer through TGF-β1/Smads signaling pathway mediated Snail/E-cadherin expression. BMC Cancer, 2015, 15:97. Link

56. Haifan Wu, Fengyu She, Wen-Yang Gao, Austin Prince, Yaqiong Li, Lulu Wei, Allison Mercer, Lukasz Wojtas, Shengqian Ma, and Jianfeng Cai.* The Synthesis of Head-to-Tail Cyclic Sulfono-γ-AApeptides. Org. Biomol. Chem., 2015, 13 (3), 672 - 676. Link

55. Haifan Wu, Qiao Qiao, Yaogang Hu, Peng Teng, Wenyang Gao, Xiaobing Zuo, Lukasz Wojtas, Randy W. Larsen, Shengqian Ma, and Jianfeng Cai.* Sulfono-γ-AApeptides as a new class of unnatural helical foldamer. Chem. Eur. J., 2015, 21, 2501-2507. Link

54. Kenneth E. Ugen, Xiaoyang Lin, Ge Bai, Zhanhua Liang, Jianfeng Cai, Kunyun Li, Shijie Song, Chuanhai Cao* and Juan Sanchez-Ramos. Evaluation of an alpha synuclein sensitized dendritic cell based vaccine in a transgenic mouse model of Parkinson's disease. Hum. Vaccin. Immunother., 2015, ASAP. Link

53. Peng Teng, Haifan Wu, Lili Lin and Jianfeng Cai.* Antimicrobial γ-AApeptides (WO2013112548)-a patent evaluation. Expert Opin. Ther. Pat., 2015, 25, 111-118. Link

2014

52. Yaogang Hu, Ni Cheng, Haifan Wu, Samuel Kang, Richard D. Ye,* and Jianfeng Cai.* Design, synthesis and characterization of fMLF-mimicking AApeptides. ChemBioChem, 2014, 15, 2420-2426. Link

 

51. Yaqiong Li, Christina Smith, Haifan Wu, Peng Teng, Yan Shi, Shruti Padhee, Torey Jones, Anh-My Nguyen, Chuanhai Cao, Hang Yin,* and Jianfeng Cai.* Short antimicrobial lipo-α/γ-AA hybrid peptides. ChemBioChem, 2014, 15, 2275-2280. Link

 

50. Peng Teng, Xiaolei Zhang, Haifan Wu, Qiao Qiao, Said M Sebti,* and Jianfeng Cai*. Identification of novel inhibitors that disrupt STAT3/DNA interaction from γ-AApeptide OBOC combinatorial library. Chem. Commun. 2014, 50 (63), 8739 - 8742. Link

 

49. Chuanhai Cao*, Yaqiong Li, Hui Liu, Ge Bai, Xiaoyang Lin, Kyle Sutherland, Jonathan Myal, Neel Nabar, Jianfeng Cai*. The potential therapeutic effects of THC on Alzheimer’s disease. J. Alz. Dis. 2014, 973-984. Link

48.Xiaoyang Lin, Ge Bai, Linda Lin, Hengyi Wu, Jianfeng Cai, Kenneth E Ugen*, Chuanhai Cao*. Vaccination induced changes in pro-inflammatory cytokine levels as an early putative biomarker for cognitive improvement in a transgenic mouse model for Alzheimer disease. Hum. Vaccin. Immunother. 2014, 10(7), 2024-2031. Link

47. Yan Wang, Frankie Costanza, Haifan Wu, Daqian Song, Jianfeng Cai* and Qi Li*. PEG-poly (amino acid)s-encapsulated Tanshinone IIA as potential therapeutics for the treatment of hepatoma. J. Mat. Chem. B. 2014, 2 (20), 3115 - 3122. Link

 

46. Yan Wang, Daqian Song, Frankie Costanza, Huirong Zhu, Zhongze Fan,* Jianfeng Cai* and Qi Li.* Targeted Delivery of Tanshinone IIA-conjugated mPEG-PLGA-PLL-cRGD Nanoparticles to Hepatocellular Carcinoma. J. Biomed. Nanotechnol. 2014, 10, 3244-3252. Link

45. Wen-Yang Gao, Yao Chen, Youhong Niu, Kia Williams, Lindsay Cash, Pastor Perez, Lukasz Wojtas , Jianfeng Cai , Yu-Sheng Chen and Shengqian Ma*. Crystal engineering of an nbo topology MOF for chemical fixation of CO2 under ambient conditions. Angew Chem. Int. Ed., 2014, 53, 2615-2619. Link.

44. Shruti Padhee, Christina Smith, Haifan Wu, Yaqiong Li, Namitha Manoj, Qiao Qiao, Zoya Khan, Chuanhai Cao, Hang Yin,* and Jianfeng Cai.* The development of antimicrobial α-AApeptides that suppress pro-inflammatory immune responses. ChemBioChem, 2014, 15, 688-694. Link

 

43. Haifan Wu, Peng Teng and Jianfeng Cai.* Rapid access to multiple classes of peptidomimetics from common γ-AApeptide building blocks. Eur. J. Org., 2014, 1760-1765. Link

 

42. Yaqiong Li, Christina Smith, Haifan Wu, Shruti Padhee, Namitha Manoj, Joseph Cardiello, Qiao Qiao, Chuanhai Cao, Hang Yin,* and Jianfeng Cai.* Lipidated Cyclic γ-AApeptides Display Both Antimicrobial and Anti-inflammatory Activity. ACS Chem. Biol., 2014, 9, 211-217. Link

 

41. Haifan Wu, Yaqiong Li, Ge Bai, Youhong Niu, Qiao Qiao, Jeremiah Tipton, Chuanhai Cao,* Jianfeng Cai.* γ-AApeptide-based small-molecule ligands that inhibit Aβ aggregation. Chem. Commun., 2014 Emerging Investigators Issue. 2014, 50 (40), 5206 - 5208. Link

 

40. Frankie Costanza, Shruti Padhee, Haifan Wu, Yan Wang, Jesse Revenis, Chuanhai Cao, Qi Li* and Jianfeng Cai.* Investigation of antimicrobial PEG-poly(amino acid)s. RSC Advances, 2014, 4, 2089-2095. Link

 

2013

39. Rongsheng E. Wang,* Yin Zhang, Ling Tian, Weibo Cai and Jianfeng Cai. Antibody-Based Imaging of HER-2: Moving into the Clinic. Curr. Mol. Med., 2013, 13, 1523-1537. Link

38. Qing Ji, Xuan Liu, Xiaoling Fu, Long Zhang, Hua Sui, Lihong Zhou, Jian Sun, Jianfeng Cai, Jianmin Qin, Jianlin Ren*, Qi Li*. Resveratrol Inhibits Invasion and Metastasis of Colorectal Cancer Cells via MALAT1 Mediated Wnt/β-Catenin Signal Pathway. PLOS One, 2013, 8, 11, e78700. Link

37. Yaqiong Li, Haifan Wu, Youhong Niu, Yaogang Hu, Qi Li, Chuanhai Cao, Jianfeng Cai.* Development of RNA Aptamer-Based Therapeutic Agents. Curr. Med. Chem., 2013, 20, 3655-3663. Link

36. Haifan Wu, Peng Teng, Youhong Niu, Qi Li, Jianfeng Cai.* Polymyxin derivatives: a patent evaluation (WO2012168820). Expert Opin. Ther. Pat., 2013, 23(8), 1075-81. Link

35. Long Zhang, Qing Ji, Xuan Liu, Xingzhu Chen, Zhaohua Chen, Yanyan Qiu, Jian Sun, Jianfeng Cai, Huirong Zhu, and Qi Li.* Norcantharidin inhibits tumor angiogenesis via blocking VEGFR2/MEK/ERK signaling pathways. Cancer Sci., 2013, 104, 604-610. Link

34. Youhong Niu, Haifan Wu, Yaqiong Li, Yaogang Hu, Shruti Padhee, Qi Li, Chuanhai Cao and Jianfeng Cai.* AApeptides as a new class of antimicrobial agents. Org. Biomol. Chem. 2013, 11, 4283-4290. Link In Celebration of Andrew D. Hamilton’s Career in Chemistry

 

2012

33. Neel R. Nabar, Fang Yuan, Xiaoyang Lin, Li Wang, Ge Bai, Jonathan Mayl, Yaqiong Li, Shu-Feng Zhou, Jinhuan Wang, Jianfeng Cai, Chuanhai Cao*. Cell Therapy: A Safe and Efficacious Therapeutic Treatment for Alzheimer’s Disease in APP+PS1 Mice. PLoS One, 2012, 7, 12, e49468. Link

32. Youhong Niu, Haifan Wu, Rongfu Huang, Qiao Qiao, Frankie Costanza, Xi-Sen Wang, Yaogang Hu, Mohamad Nassir Amin, Anh-My Nguyen, James Zhang, Edward Haller, Shengqian Ma, Xiao Li, and Jianfeng Cai*. Nanorods formed from a new class of peptidomimetics. Macromolecules, 2012, 45, 7350–7355. Link

31. Youhong Niu, Rongsheng E. Wang*, Haifan Wu, Jianfeng Cai*. Recent development of small antimicrobial peptidomimetics. Future Med. Chem. 2012, 4, 14, 1853-1862. Link

30. Yaogang Hu, Mohamad Nassir Amin, Shruti Padhee, Rongsheng E. Wang, Qiao Qiao, Ge Bai, Yaqong Li, Archana Mathew, Chuanhai Cao, and Jianfeng Cai*. Lipidated Peptidomimetics with Improved Antimicrobial Activity. ACS Med. Chem. Lett. 2012, 3, 683-686. Link

29. Haifan Wu, Mohamad Nassir Amin, Youhong Niu, Qiao Qiao, Nassier Harfouch, Abdelfattah Nimer, Jianfeng Cai*. Solid Phase Synthesis of γ-AApeptides Using a Novel Submonomeric Approach. Org. Lett. 2012, 14, 3446-3449. Link


28. Yunan Yang, Youhong Niu, Hao Hong, Haifan Wu, Yin Zhang, Jonathan W. Engle, Todd E. Barnhart, Jianfeng Cai*, and Weibo Cai*. Radiolabeled γ-AApeptides: A New Class of Tracers for Positron Emission Tomography. Chem. Commun. 2012, 48, 7850-7852. Link

 

27. Haifan Wu, Youhong Niu, Shruti Padhee, Rongsheng E Wang, Yaqiong Li, Qiao Qiao, Ge Bai, Chuanhai Cao, and Jianfeng Cai*. Design and synthesis of unprecedented cyclic γ-AApeptides for antimicrobial development. Chem. Sci., 2012, 3, 2570-2575. Link


26. Zhongqiu Luo, Jialin Li, Neel R. Nabar, Xiaoyang Lin, Ge Bai, Jianfeng Cai, Shu-Feng Zhou, Chuanhai Cao*, Jinhuan Wang*. Efficacy of a Therapeutic Vaccine Using Mutated β-amyloid Sensitized Dendritic Cells in Alzheimer’s Mice. J. Neuroimmune Pharmacol., 2012, 7, 640-645. Link

25. Wen-Yang Gao , Youhong Niu , Yao Chen , Lukasz Wojtas , Jianfeng cai , Yu-Sheng Chen and Shengqian Ma*. Porous Metal-Organic Framework Based on a Macrocyclic Tetracarboxylate Ligand Exhibiting Selective CO2 Uptake. CrystEngComm, 2012, 14, 6115-6117. Link

24. Youhong Niu, Shruti Padhee, Haifan Wu, Ge Bai, Qiao Qiao, Yaogang Hu, Lacey Harrington, Whittney N. Burda, Lindsey N. Shaw, Chuanhai Cao, and Jianfeng Cai*. Lipo-γ-AApeptides as a new class of potent and broad-spectrum antimicrobial agents. J. Med. Chem. 2012, 55(8), 4003–4009 Link


23. Chuanhai Cao*, David A. Loewenstein, Xiaoyang Lin, Chi Zhang, Li Wang, Ranjan Duara, Yougui Wu, Alessandra Giannini, Ge Bai, Jianfeng Cai, Maria Greig, Elizabeth Schofield, Raj Ashok, Brent Small, Huntington Potter and Gary W. Arendash*. High Blood Caffeine Levels in MCI Linked to Lack of Progression to Dementia. J. Alz. Dis. 2012, 30, 559-572. Link

22. Youhong Niu, Ge Bai, Haifan Wu, Rongsheng E. Wang, Qiao Qiao, Shruti Padhee, Robert Buzzeo, Chuanhai Cao*, and Jianfeng Cai*. Cellular translocation of a γ-AApeptide mimetic of Tat peptide. Mol. Pharmaceutics. 2012, 9(5), 1529–1534 Link


21. Ge Bai, Shruti Padhee, Youhong Niu, Rongsheng E. Wang, Robert Buzzeo, Chuanhai Cao*, and Jianfeng Cai*. Cellular uptake of an α-AApeptide. Org. Biomol. Chem. 2012, 10 (6), 1149 - 1153. Link


20. Rongsheng E. Wang,* Frankie Costanza, Youhong Niu, Haifan Wu, Yaogang Hu, Whitney Hang, Yiqun Sun, Jianfeng Cai.* Development of self-immolative dendrimers for drug delivery and sensing. J. Control. Release. 2012, 159, 154-163. Link

19. Rongsheng E. Wang, Youhong Niu, Haifan Wu, Yaogang Hu, Jianfeng Cai*. Development of NGR-Based Anti-Cancer Agents for Targeted Therapeutics and Imaging. Anticancer Agents Med. Chem. 2012, 12 (1), 76-86. Link

2011

18. Youhong Niu, Shruti Padhee, Haifan Wu, Ge Bai, Lacey Harrington, Whitney N. Burda, Lindsey N. Shaw, Chuanhai Cao, and Jianfeng Cai*. Identification of γ-AApeptides with potent and broad-spectrum antimicrobial activity. Chem. Commun. 2011, 47 (44), 12197 - 12199. Link

 

17. Rongsheng E. Wang, Yin Zhang, Jianfeng Cai, Weibo Cai, Ting Gao*. Aptamer-Based Fluorescent Biosensors. Curr. Med. Chem. 2011, 18, 4175-4184. Link

16. Rongsheng E. Wang,* Haifan Wu, Youhong Niu, and Jianfeng Cai*. Improving the Stability of Aptamers by Chemical Modification. Curr. Med. Chem. 2011, 18, 4126-4138. Link

15. Rongsheng E. Wang, Youhong Niu, Haifan Wu, Mohamad Nassir Amin, and Jianfeng Cai*. Development of NGR peptide-based agents for tumor imaging. Am. J. Nucl. Med. Mol. Imaging 2011;1(1):36-46. Link

14. Shruti Padhee, Yaogang Hu, Youhong Niu, Ge Bai, Haifan Wu, Frankie Costanza, Leigh West, Lacey Harrington, Lindsey N. Shaw, Chuanhai Cao, and Jianfeng Cai*. Non-Hemolytic α-AApeptides as Antimicrobial Peptidomimetics. Chem. Commun. 2011, 47 (34), 9729 - 9731 Link


13. Youhong Niu, Alisha “Jonesy” Jones, Haifan Wu, Gabriele Varani,* and Jianfeng Cai.* γ-AApeptides bind to RNA by mimicking RNA-binding proteins. Org. Biomol. Chem., 2011, 9 (19), 6604 - 6609. Link


12. Youhong Niu, Yaogang Hu, Xiaolong Li, Jiandong Chen, and Jianfeng Cai*. Gamma-AApeptides: Design, Synthesis and Evaluation. New J. Chem. 2011, 35, 542-545. Link


11. Yaogang Hu, Xiaolong Li, Said M. Sebti, Jiandong Chen, and Jianfeng Cai*. Design and Synthesis of AApeptides: A New Class of Peptide Mimics. Bioorg. Med. Chem. Lett., 2011, 21, 1469-1471. Link

 

From Doctoral and Postdoctoral Work:

10. Rongsheng E. Wang, Raj K. Pandita, Jianfeng Cai, Clayton R. Hunt, John-Stephen Taylor*. Inhibition of Heat Shock Transcription Factor Binding by a Linear Polyamide Binding in an Unusual 1:1 Mode. ChemBioChem, 2012, 13(1), 97-104. Link

9. Sourav Saha, Jianfeng Cai, Daniel Eiler and Andrew D. Hamilton*. Programing the formation of DNA and PNA quadruplexes by pi-pi stacking interactions. Chemcomm., 2010, 46, 1685-1687. Link

8. Yao Cheng, Lun K. Tsou, Jianfeng Cai, Toshihiro Aya, Ginger E. Dutschman, Elizabeth A. Gullen, Susan P. Grill, Annie Pei-Chun Chen, Brett D. Lindenbach, Andrew D. Hamilton, Yung-chi Cheng*. A novel class of meso-tetrakis-porphyrin derivatives exhibit potent activities against hepatitis C virus genotype 1b replicons in vitro. Antimicrob. Agents Chemother. 2010, 54(1), 197-206. Link

7. Jianfeng Cai, Dariusz Niedzwiedzki, Harry A. Frank*,and Andrew D. Hamilton*. Ultrafast energy transfer within pyropheophorbide-a tethered to self-assembling DNA Quadruplex. ChemComm., 2010, 46, 544 - 546. Link

6. Jianfeng Cai, Brooke Rosenzweig, and Andrew D. Hamilton*. Inhibition of Chymotrypsin by a self-assembled DNA quadruplex functionalized with cyclic peptide binding fragments. Chem. Eur. J., 2009, 15(2), 328-332. Link

5. Jianfeng Cai, Erik M. Shapiro*, and Andew D. Hamilton*. Self-assembled DNA quadruplex conjugated to MRI contrast agent. Bioconjugate Chem., 2009, 20(2), 205-208. Link

4. Jianfeng Cai, Xiaoxu Li, and John Stephen Taylor*. Improved nucleic acid triggered probe activation through the use of a 5-thiomethyluracil peptide nucleic acid building block. Org. Lett .; 2005, 7(5), 751-754. Link

3. Jianfeng Cai, Xiaoxu Li, Xuan Yue, and John Stephen Taylor*. Nucleic acid-triggered fluorescent probe activation by the Staudinger reaction. J. Am. Chem. Soc., 2004, 126(50), 16324-16325. Link

2. Yun Lu*, Jianfeng Cai and Gi Xue. Molecular design of a soft interphase and its role in the reinforcement and toughening of aluminum powder-filled polyurethane. Journal of Adhesion Science and Technology, 2001, 15, 71-82. Link

1. Jianfeng Cai, Yun Lu*, Gi Xue and Wei Zhang. The reinforcement of Al filled Polyurethane system. Modern Plastics Processing and Applications, 1999, 11 (6), 10.

PATENT APPLICATIONS

12. Jianfeng Cai, Peng Teng. Novel Bis-cyclic guanidines as antibacterial agents, 2017, 62/536,295.

11. Jianfeng Cai, Yan Shi. One-Bead-Two-Compound Macrocyclic Library and Methods of Preparation and Use, 2017, 62/483,038.

10. Vrushank Dave, Jianfeng Cai. PTEN Binding Compounds, Formulations, and Uses Thereof, 2017, 62/460,324.

9. Jianfeng Cai, Ma Su, Alekhya Nimmagadda, Peng Teng. Cationic hydantoin compounds and the use of, 2016, 62/426,698

8. Niketa A. Patel, Jianfeng Cai. GAS5 BINDING COMPOUNDS, FORMULATIONS, AND USES THEREOF, 2016, 62/398,624.

7. Said M. Sebti and Jianfeng Cai. Stapled peptides designed to inhibit the mutantt KRas/ Raf interaction, 2016, WO 172,187 A1.

6. Jianfeng Cai, Chuanhai Cao, Haifan Wu, Yaqiong Li, and Ge Bai. Methods of Synthesizing γ-AApeptides, γ-AApeptide Building Blocks, γ-AApeptide Libraries, and γ-AApeptide Inhibitors of Abeta40 Aggregates, 2016, 0209422 A1.

5. Jianfeng Cai, Youhong Niu, Weibo Cai, and Hao Hong. RGD mimetic γ-AApeptides and methods of use. 2016, US 9,234,007 B2, issued

4. Jianfeng Cai, Youhong Niu, Haifan Wu, Shruti Padhee. Identification of γ-AApeptides with potent and broad-spectrum antimicrobial activity. 2016, US 9,499,587 B2, issued

3. Said M. Sebti and Jianfeng Cai. Gamma-AApeptide stat3/DNA inhibitors and methods of use, 2014, Application No. 61/984179.

2. Nathan J. Rice, Lennox Hoyte, and Jianfeng Cai. Materials and methods for reliable measurement of blood volume. 2011, PCT Int. Appl. WO 2011130304. Link

Prior to USF

1.  Gi Xue, Lu Yun, Jianfeng Cai, Li Fengting and Du lei. The preparation of Al/PU composite Reinforced by Organic molecules containing Sulfur or Nitrogen atoms. CN 1276394A, Appl. 99114246.2, 1999. Link

BOOK CHAPTERS

5. Olapeju Oyesiku and Jianfeng Cai.* Peptidomimetic agents targeting bacteria. Comprehensive Supramolecular Chemistry II. Elsevier, 2016, accepted.

4. Peng Teng, Haifan Wu and Jianfeng Cai*. Peptidomimetics as antimicrobial agents. Book: Novel Antimicrobial Agents and Strategies. Wiley, 2014, ISBN: 978-3-527-33638-8.

3. Haifan Wu and Jianfeng Cai*. Engineering AApeptides for Translational Medicine. Link Engineering in Translational Medicine, 2013, ISBN: 978-1-62703-651-1.

2. Youhong Niu, Yaogang Hu, Haifan Wu, and Jianfeng Cai*. Synthesis of AApeptides. Link. Peptide Modifications to Increase Metabolic Stability and Activity, 2013, ISBN: 978-1-62703-651-1.

1. Youhong Niu, Yaogang Hu, Rongsheng E. Wang, Xiaolong Li, Haifan Wu, Jiandong Chen* and Jianfeng Cai*. AApeptides as a New Class of Peptidomimetics to Regulate Protein-Protein Interactions. Link. Protein Interactions, 2012, ISBN: 978-953-51-0244-1.